Use in Adults
THIS GUIDE PROVIDES A PARTIAL LISTING OF PRESCRIBING INFORMATION FOR THIS MEDICATION. FOR A FULL LISTING OF PRESCRIBING INFORMATION PLEASE REFER TO THE PACKAGE INSERT. CLICK ON THE BRAND NAME® TO VIEW THE LINK TO THE PACKAGE INSERT.
LASMIDITAN (REYVOW®) CLICK HERE TO EXPAND)
Precautions and Risk:
- 50 and 100 mg tablets
- 100 mg is the preferred starting dose
- May use 50 mg dose if 100 mg dose is not tolerated
- May use two 100 mg tablets (total dose of 200mg) as starting dose if not pain free or adequate pain relief with lower dosages
- Take one dose (50 mg, 100 mg or 200 mg) at onset of migraine attack as needed for the treatment of an acute migraine attack
- No evidence for benefit from second dose
- 200 mg
- Dizziness (severe 1% and mild to moderate in 15-20%)
- Sedation, fatigue, paresthesia
- Consider use in the following patients:
- Primary therapy in those with known cardiovascular disease or other contraindications to use of the triptans
- Used as rescue therapy for those not attaining an adequate response after 2 hours to the initial dosage of an acute medication
- There is no evidence from clinical studies that ditans are more efficacious than triptans, gepants or ergots.
- The main advantages of lasmiditan are early pain free efficacy, despite treating later in a migraine attack (from clinical trial data) and its lack of a cardiovascular contraindication to its use.
Precautions and Risk:
- Lasmiditan should not be taken unless the patient can wait at least 8 hours between dosing and driving or operating machinery.
- Lasmiditan is a Schedule V controlled substance (C-V). Avoid in patients with history of substance abuse.
- Click Reyvow® and navigate to #8 Use in Specific Populations (8.1 & 8.2)
- Use with caution with any other CNS depressants known to cause sedation, to avoid combination effect
- Be vigilant for development of serotonin syndrome in those receiving other serotonergic medications
- May decrease heart rate when administered with a negative chronotropic drug
- It is unknown if lasmiditan is associated with serotonin syndrome when used along with other serotonergic medications.
- Might be best administered when at home when no need to drive for 8 hours;